ScienceDirecthttps://www.sciencedirect.com/science/article/pii/S2211383524003113Precise targeting of lipid metabolism in the era of immuno …2024年7月27日 · Lipid metabolism and the malignant phenotype of tumors are highly intertwined. Lipids, diverse compounds like fatty acids (FAs), phospholipids (PLs), cholesterol (Chol), and signaling molecules, including bioactive lipids such as prostaglandin E2 (PGE2) and lysophosphatidic acid (LPA), play vital roles in signaling and energy supply within the TME, …

PubMedhttps://pubmed.ncbi.nlm.nih.gov/34553434The review of alpha-linolenic acid: Sources, metabolism, and ...α-linolenic acid (ALA, 18:3n-3) is a carboxylic acid composed of 18 carbon atoms and three cis double bonds, and is an essential fatty acid indispensable to the human body. This study aims to systematically review related studies on the dietary sources, metabolism, and pharmacological effects of ALA …

The Lancethttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00059-7/fullt…Pharmacotherapy of obesity: an update on the available …Obesity is an epidemic and a public health threat. Medical weight management remains one of the options for the treatment of excess weight and recent advances have revolutionized how we treat, and more importantly how we will be treating obesity in the near future. Metreleptin and Setmelanotide are currently indicated for rare obesity syndromes, and 5 other medications …

ScienceDirecthttps://www.sciencedirect.com/science/article/pii/S0010482519300083In silico approaches and tools for the prediction of drug metabolism ...2019年3月1日 · As our understanding of drug fate–determining metabolic reactions has increased, drug metabolism has attracted greater attention as a critical factor in drug discovery [[1], [2], [3]].The fate of substances such as drugs and xenobiotics administered into our body is largely governed by the three phases of drug metabolism: phase I, introduction of a reactive group by …